Sunday, February 18, 2018

Dual LABA/LAMA bronchodilators in COPD: why? when? and how?

Dual LABA/LAMA bronchodilators in COPD: why? when? and how?
Still many questions in our real everyday practice!
Read Editorial in Expert Review of Respiratory Medicine by great Italian team conducted by professor Mario Cazzola. 
LABA/LAMA combinations induce bronchorelaxant synergistic interaction when the drugs mixture is well-balanced and administered at low isoeffective concentrations.
The overall approach of Drug Companies has been to combine in a FDC a LABA and a LAMA at the same doses for which the monocomponents were previously approved. Indeed, this practice does not permit to optimize the synergy in the final
LABA/LAMA FDCs. Conversely, dose-finding studies are required to identify the correct dose-ratio and establish the minimal doses for each monocomponent in the FDC leading to the greater synergism with regard to the improvement in lung
function, symptoms, and exacerbations.
Furthermore, although LABA/LAMA FDCs are characterized by an acceptable safety profile, the cardiovascular toxicity of LABAs and LAMAs may overlap. Thus, postmarketing surveillance and observational studies are needed to assess the real risk of rare, but potentially serious, cardiovascular adverse events associated with the dual bronchodilation therapy in COPD patients.
Full text:

2 comments:

  1. I was diagnosed with COPD with 55-60% lung capacity. and Hiv, My doctor just said all the crying , stomping your feet will not change it so just accept it and basically patted me on the back and sent me home to die. I was devastated and was afraid to do anything. I stopped riding my bike, I was afraid to do anything that would cause any exertion. It consumed my thoughts with every breath and the fear of what to expect was almost more than I could deal with. So I couldn't get myself all time I decided to find a herbal cure online and I came across Doctor Itua on how he cure several people suffering from Hiv, and Herpes I gave him a call on this Number +2348149277967 also chat on whatsapp he gave me all the details about the cure i paid him for the medicine after 5 working days i receive my herbal medicine ,I use it for two weeks that is how I get Cured and today I'm living healthy and  fine I give him thanks also promise him to testify about his work,He Can also cure the following diseases..Copd,Herpes,Alzheimer's disease,carcinoma.Asthma,Allergic diseases.Parkinson's ,Epilepsy,Cancer,Fibromyalgia,Hiv,Hepatitis,diabetes,Coeliac disease,Infertility, Asthma.Contact...drituaherbalcenter@gmail.com..Whatsapp Number...+2348149277976

    ReplyDelete
  2. I started on COPD Herbal treatment from Ultimate Health Home, the treatment worked incredibly for my lungs condition. I used the herbal treatment for almost 4 months, it reversed my COPD. My severe shortness of breath, dry cough, chest tightness gradually disappeared. Reach Ultimate Health Home via their email at ultimatehealthhome@gmail.com . I can breath much better and It feels comfortable!

    ReplyDelete