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Wednesday, July 15, 2015

2015 guidelines for the treatment of idiopathic pulmonary fibrosis released by leading respiratory societies

Updated guidelines on the treatment of idiopathic pulmonary fibrosis (IPF) have been released by an international group of leading respiratory societies, The new guidelines, issued by the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, and the Latin American Thoracic Association, were published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
"In these updated guidelines, we analyzed new evidence reported since our 2011 guideline was issued and updated our treatment recommendations accordingly," said Ganesh Raghu, MD, Professor of Medicine, University of Washington, director of the Center for Interstitial Lung Disease, UW Medicine at the University of Washington Medical Center, and chair of the committee that produced the guidelines. "The updated guidelines do not recommend one treatment regimen over another. All of these recommendations must be weighed individually, considering all the factors used to grade each one, including the confidence in effect estimates, evidence from outcomes studies, desirable and undesirable consequences of treatment, treatment costs, the implications of treatment on health equity, and the feasibility of treatment," Raghu added.
Evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach, with recommendations rated as either "strong" or "conditional." Conditional recommendations are synonymous with weak recommendations.
http://www.atsjournals.org/doi/abs/10.1164/rccm.201506-1063ST#.VacvmfkXyUn

The following recommendations are new or revised from the 2011 guidelines:
  • The recommendation against the use of the following agents for the treatment of IPF is strong:
    • Anticoagulation (warfarin)
    • Imatinib, a selective tyrosine kinase inhibitor against platelet-derived growth factor (PDGF) receptors
    • Combination prednisone, azathioprine, and N-acetylcysteine
    • Selective endothelin receptor antagonist (ambrisentan)
  • The recommendation for the use of the following agents for the treatment of IPF is conditional:
    • Nintedanib, a tyrosine kinase inhibitor that targets multiple tyrosine kinases, including vascular endothelial growth factor, fibroblast growth factor, and PDGF receptors
    • Pirfenidone
  • The recommendation against the use of the following agents for the treatment of IPF is conditional:
    • Phosphodiesterase-5 inhibitor (sildenafil)
    • Dual endothelin receptor antagonists (macitentan, bosentan)
Recommendations remaining unchanged from the 2011 guidelines include a conditional recommendation against the use of N-acetylcysteine monotherapy for IPF and a conditional recommendation for the use of antiacid therapy.
"Our systematic review of the available evidence on IPF treatments points to the need for additional research and long-term studies of their safety and efficacy," said Dr. Raghu. "This is especially true for treatments that received conditional recommendations in the guidelines. The guidelines empower the clinician to make the most appropriate treatment choices for the patient confronted with IPF and encourage shared decision-making with the well informed patient to choose the most appropriate treatment options tailored to the individual patient's needs," emphasized Raghu.

2 comments:

  1. After years of working in construction and smoking cigarettes,I was diagnosed with COPD and pulmonary fibrosis. As my illness progressed, I found myself  relying on supplemental oxygen around the clock. Even getting out of bed became a challenge.My doctors and specialists recommended a lung transplant, but after researching the pros and cons of such a drastic procedure, I decided to try something less invasive. I contacted multivitamin herbal cure cape town for organic natural treatment you can search for them on google. Following the COPD and pulmonary fibrosis herbal treatment procedure , my lung function has improved dramatically after my first four weeks of the herbal formula .My quality of life has gotten a lot better. I was amazed that I could breathe without any dead air. I no longer need oxygen and look forward to continued improvement because a specialist told me already I have a chance of getting rid of my condition totally due to the herbal treatment effectiveness . If you or someone you love has COPD, pulmonary fibrosis or another chronic lung disease, and would like to see improvements like mine they even guarantee me totally cure once the treatment is done , their website multivitamincare org they will put you through on the herbal process .

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  2. I was diagnosed in 2013 with pulmonary fibrosis and in early 2014 was told it was idiopathic pulmonary fibrosis (IPF). Next thing I found was I would need to carry around oxygen wherever I went and use it at home and while I slept. I was given a couple of years. In 2018 I was told by a holistic nurse practitioner to try multivitamin herbal treatment because my condition was getting worse. I used the herbal formula in March 2018. My lifestyle has changed since all this began. I consume no alcohol, walk more than I used to and without oxygen, and am able to control my weight much better than before.All of this has changed. I exercise and walk daily, play catch and dance with my grandchildren, I use the organic remedy for over 4 month without any further usage or side effects . I can only speak for myself, but I highly recommend www multivitamincare. org treatment for those who know the feeling of gasping for air as I did.

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