Dear Respiratory friends, we are happy to present you exciting story of discovery of roflumilast for the treatment of COPD by great Italian team: Mario Cazzola, Luigino Calzetta, Paola Rogliani & Maria Gabriella Matera.
Introduction: Cyclic adenosine
monophosphate (cAMP) phosphodiesterase (PDE)4 is an intracellular target
that can be exploited to the treat chronic obstructive pulmonary
disease (COPD), given that it is expressed in all inflammatory cells
implicated in this inflammatory airways disease. At the present time,
roflumilast is the only PDE4 inhibitor that has received regulatory
approval for use in patients with COPD.
Areas covered:
The preclinical, clinical and post-marketing development of roflumilast
is described. Furthermore, a critical analysis of the clinical data and
positioning of this drug is undertaken in this review
Expert opinion:
The identification of a subset of COPD patients, namely those suffering
from severe airflow obstruction with symptoms of chronic cough and
sputum and a history of previous exacerbations, as a specific target for
roflumilast with the goal of reducing exacerbations, was entirely
casual because the delineation of a “chronic bronchitis” responder group
was clearly a post-hoc finding. However, it was useful to design
prospective clinical trials that demonstrated reduced exacerbations in
this specific subset of patients towards whom roflumilast therapy is now
targeted. However, these pivotal trials still do not provide more
accurate identification of the type of exacerbation to be treated by
roflumilast. The identification of the right biological COPD
exacerbation phenotype and/or the right clinical COPD phenotype are the
only means that could justify the use of roflumilast as a first line
anti-inflammatory therapeutic approach.
full text:
Here is a great herbal doctor who cured me of Hepatitis B. his name is Dr. Imoloa. I suffered Hepatitis B for 11 years, I was very weak with pains all over my body my stomach was swollen and I could hardly eat. And one day my brother came with a herbal medicine from doctor Imoloa and asked me to drink and I drank hence there was no hope, and behold after 2 week of taking the medicine, I started feeling relief, my swollen stomach started shrinking down and the pains was gone. I became normal after the completion of the medication, I went to the hospital and I was tested negative which means I’m cured. He can also cure the following diseases with his herbal medicine...lupus, hay fever, measles, dry cough, diabetics hepatitis A.B.C, mouth ulcer, mouth cancer, bile salt disease, fol ate deficinecy, diarrhoea, liver/kidney inflammatory, eye cancer, skin cancer disease, malaria, chronic kidney disease, high blood pressure, food poisoning, parkinson disease, bowel cancer, bone cancer, brain tumours, asthma, arthritis, epilepsy, cystic fibrosis, lyme disease, muscle aches, cholera, fatigue, muscle aches, shortness of breath, alzhemer's disease, acute myeloid leukaemia, acute pancreatitis, chronic inflammatory joint disease, inflammatory bowel disease, Addison's disease back acne, breast cancer, allergic bronchitis, Celia disease, bulimia, congenital heart disease, cirrhosis, fetal alcohol spectrum, constipation, fungal nail infection, fabromyalgia, (love spell) and many more. he is a great herbalist man. Contact him on email; drimolaherbalmademedicine@gmail.com. You can also reach him on whatssap- +2347081986098.
ReplyDeleteI started on COPD Herbal treatment from Ultimate Health Home, the treatment worked incredibly for my lungs condition. I used the herbal treatment for almost 4 months, it reversed my COPD. My severe shortness of breath, dry cough, chest tightness gradually disappeared. Reach Ultimate Health Home via their email at ultimatehealthhome@gmail.com . I can breath much better and It feels comfortable!
ReplyDelete