The morbidity and mortality of chronic obstructive pulmonary
disease (COPD) continues in an uninterrupted fashion; current treatment
options are limited, and there is no cure. Failure to diagnose COPD
early, poor correlation of airflow obstruction with the extent and type
of structural impairment, the number of comorbid conditions, and the
lack of an adequate animal model for COPD account for our current
inability to transform COPD treatment. Fortunately the tide is beginning
to turn.
The medical research community has recognized these problems
and has embarked on multiple paths of scientific inquiry to understand
COPD pathogenesis, the clinical phenotypes, and treatments that are
truly novel by using compounds that inhibit pathways of lung injury and
aberrant responses of repair. The following are examples of the research
work conducted on COPD in 2015 that attempt to address many of the
questions that need to be answered to achieve the common goal of not
only improving the care of patients with COPD but also curing them of
this devastating disease.
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