Dear Friends, we are happy to present you our new article published online yesterday in Respiration!
Background:
Chronic obstructive pulmonary disease (COPD) is a major cause of
morbidity in the elderly population. COPD leads to a reduced
health-related quality of life (HRQL), but the factors which contribute
to this are not well understood. A better understanding of the factors
which determine HRQL should lead to an improved care for such patients.
Objectives: The purpose of this study was to investigate possible
age-related differences in HRQL in a population of patients with a
similar severity of obstruction.
Methods: A total of 180 consecutive
COPD patients were enrolled into the study. We analyzed spirometric
data, BODE index and its components, and comorbidities were assessed by
the Charlson index. HRQL was assessed by the Clinical COPD Questionnaire
(CCQ) and St. George's Respiratory Questionnaire (SGRQ). Results: The
cohort consisted of 93 ‘younger' patients (mean age 54.8 ± 3.1 years)
and 87 older patients (mean age 73.1 ± 5.5 years). Patients in both
groups had a similar severity of obstruction: FEV1 (% from predicted)
was 39.9 ± 13.2% in the elderly group compared to 41.7 ± 11.7% in the
younger group (p > 0.05). The forward stepwise regression analysis
shows that the BODE index, the Charlson index, and the rate of
exacerbations are important predictors of deterioration of HRQL in
elderly COPD patients, which explains 29% of the total SGRQ score. In
the younger COPD patients, the coefficient of determination R2 was 0.27,
but the predictors were the BODE index and the rate of exacerbations.
Conclusions: The BODE index, the Charlson index, and the rate of
exacerbations were found to be the major determinants of HRQL in elderly
COPD patients, while in younger COPD patients, the BODE index and the
rate of exacerbations were influential factors.
Full text:
Researchgate:
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