Clinical phenotyping is currently used to guide
pharmacological treatment decisions in chronic obstructive pulmonary
disease (COPD), a personalized approach to care. Precision medicine
integrates biological (endotype) and clinical (phenotype) information
for a more individualized approach to pharmacotherapy, to maximize the
benefit versus risk ratio. Biomarkers can be used to identify endotypes.
To evolve toward precision medicine in COPD, the most appropriate
biomarkers and clinical characteristics that reliably predict treatment
responses need to be identified.
FEV1 is a marker of COPD
severity and has historically been used to guide pharmacotherapy
choices. However, we now understand that the trajectory of FEV1 change, as an indicator of disease activity, is more important than a single FEV1
measurement. There is a need to develop biomarkers of disease activity
to enable a more targeted and individualized approach to
pharmacotherapy. Recent clinical trials testing commonly used COPD
treatments have provided new information that is likely to influence
pharmacological treatment decisions both at initial presentation and at
follow up. In this Perspective, we consider the impact of recent
clinical trials on current COPD treatment recommendations. We also focus
on the movement toward precision medicine and propose how this field
needs to evolve in terms of using clinical characteristics and
biomarkers to identify the most appropriate patients for a given
pharmacological treatment.
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I'm 59 years old and female. I was diagnosed a couple of years ago with COPD and I was beyond scared! My lung function test indicated 49% capacity. After having had flu a year ago, the shortness of breath, coughing and chest pains continued even after being treated with antibiotics. I've been smoking two packs a day for 36 years. Being born without a sternum caused my ribs to be curled in just one inch away from my spine, resulting to underdeveloped lungs. At age 34 I had surgery and it was fixed. Unfortunately my smoking just caused more damage to my already under developed lungs. The problem was having is that I enjoy smoking and don't want to give up! Have tried twice before and nearly went crazy and don't want to go through that again. I saw the fear in my husband and children's eyes when I told them about my condition then they start to find solution on their own to help my condition.I am an 59 now who was diagnose COPD emphysema which I know was from my years of smoking. I started smoking in school when smoking was socially acceptable. I remember when smoking was permitted in hospitals. It was not known then how dangerous cigarettes were for us, and it seemed everybody smoked but i was able to get rid of my COPD lung condition through the help of total cure herbal foundation my husband bought, totalcureherbsfoundation . com has the right herbal formula to help you get rid and repair any lung conditions and cure you totally with their natural organic herbs,it class products at affordable prices because how awful it is with this lung dictions . I wish anybody who starts smoking at a young age would realize what will eventually happen to their bodies if they continue that vile habit throughout their life, certainly total cure herbs is the formula to get over Chronic Obstructive Pulmonary Disease.
ReplyDeleteI started on COPD Herbal treatment from Ultimate Life Clinic, the treatment worked incredibly for my lungs condition. I used the herbal treatment for almost 4 months, it reversed my COPD. My severe shortness of breath, dry cough, chest tightness gradually disappeared. Reach Ultimate Life Clinic via their website www.ultimatelifeclinic.com . I can breath much better and It feels comfortable!
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