Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous and
complex disease with great morbidity and mortality. Despite the new
developments in the managements of COPD, it was recognized that not all
patients benefit from the available medications. Therefore, efforts to
identify subgroups or phenotypes had been made in order to predict who
will respond to a class of drugs for COPD.
This review will discuss
phenotypes, endotypes, and subgroups such as the frequent exacerbator,
the one with systemic inflammation, the fast decliner, ACOS, and the one
with co-morbidities and their impact on therapy. It became apparent,
that the “inflammatory” phenotypes: frequent exacerbator, chronic
bronchitic, and those with a number of co-morbidities need inhaled
corticosteroids; in contrast, the emphysematous type with dyspnea and
lung hyperinflation, the fast decliner, need dual bronchodilation
(deflators). However, larger, well designed studies clustering COPD
patients are needed, in order to identify the important subgroups and
thus, to lead to personalize management in COPD.
This is an Accepted Manuscript of an article published by Taylor
& Francis in COPD: Journal of Chronic Obstructive Pulmonary Disease on 7 April 2017, available
online: http://www.tandfonline.com/eprint/JjF9xAcnsrjwNYAuysBI/full
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