Chronic obstructive pulmonary disease and asthma are the most frequent
chronic respiratory diseases that affect the general population. For a
long period of time these two conditions were considered to be separate
diseases. However, it became evident that some patients share symptoms
and clinical findings from both diseases.
These patients are considered
to represent a distinct phenotype, called asthma-COPD overlap syndrome
(ACOS). However, since approximately the one third of the asthmatics
smoke the ACOS may primarily define those patients. This is a relatively
newly defined clinical syndrome whose underlying mechanisms and most
appropriate management remain to be confirmed. In this review, we
summarize current knowledge on this syndrome, aiming to update
clinicians and help their daily practice.
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