Dear Respiratory Friends, we are happy to present you fresh article Impact of anemia on short-term survival in severe COPD exacerbations: a cohort study from Journal of COPD by our Turkish friends Begum Ergan and Recai Ergün!!!
Purpose: Anemia is reported to be an independent
predictor of hospitalizations and survival in COPD. However, little is
known of its impact on short-term survival during severe COPD
exacerbations. The primary objective of this study was to determine
whether the presence of anemia increases the risk of death in acute
respiratory failure due to severe COPD exacerbations.
Patients and methods: Consecutive
patients with COPD exacerbation who were admitted to the intensive care
unit with the diagnosis of acute respiratory failure and required
either invasive or noninvasive ventilation (NIV) were analyzed.
Results:
A total of 106 patients (78.3% male; median age 71 years) were included
in the study; of them 22 (20.8%) needed invasive ventilation
immediately and 84 (79.2%) were treated with NIV. NIV failure was
observed in 38 patients. Anemia was present in 50% of patients, and 39
patients (36.8%) died during hospital stay. When compared to nonanemic
patients, hospital mortality was significantly higher in the anemic
group (20.8% vs 52.8%, respectively; P=0.001). Stepwise
multivariate logistic regression analysis showed that presence of anemia
and NIV failure were independent predictors of hospital mortality with
odds ratios (95% confidence interval) of 3.99 ([1.39–11.40]; P=0.010) and 2.56 ([1.60–4.09]; P<0.001), respectively. Anemia was not associated with long-term survival in this cohort.
Conclusion: Anemia may be a risk factor for hospital death in severe COPD exacerbations requiring mechanical ventilatory support.
Conclusion: Anemia may be a risk factor for hospital death in severe COPD exacerbations requiring mechanical ventilatory support.
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