Respiratory symptoms may result from a wide spectrum of pulmonaryconditions that includes both HIV-related and non-HIV-related conditions. The HIV-related conditions include
both OIs and neoplasms. The OIs include bacterial, mycobacterial,
fungal, viral, and parasitic pathogens. OIs and neoplasms may be limited
to the lungs, but pulmonary involvement may be only one manifestation
of a multiorgan disease. Because prompt diagnosis and institution of
appropriate therapy are essential for successful treatment of many of
these HIV-related conditions, the initial focus of the evaluation of
respiratory symptoms frequently and appropriately is placed on the
diagnosis of an HIV-related OI or neoplasm. It is important to remember,
however, that HIV-infected patients may have preexisting conditions or
may develop conditions (eg, pulmonary embolism, asthma, or bronchogenic
carcinoma in a cigarette smoker) unrelated to HIV infection that may
cause respiratory complaints. In addition, factors that contribute to
HIV infection, such as injection drug use (IDU), may contribute to
respiratory disease (eg, pulmonary vascular disease). Clinicians should
carefully consider these non-HIV-related respiratory conditions before
embarking on an exhaustive search for an HIV-related OI or neoplasm.
The
Pulmonary Complications of HIV Infection Study demonstrated that upper
respiratory tract infections (URIs) such as sinusitis, pharyngitis, and
acute bronchitis were more commonly the cause of respiratory symptoms
than Pneumocystis jiroveci pneumonia (PCP), bacterial pneumonia, tuberculosis (TB), or pulmonary Kaposi sarcoma combined. This spectrum of pulmonary illnesses dominated by URIs and acute
bronchitis in an outpatient-based clinical setting clearly shifts toward
the opportunistic pneumonias in an inpatient- or hospital-based
clinical setting, and it shifts toward PCP in an intensive care
unit-based clinical setting.
In addition, demographic and regional differences will affect the
spectrum of pulmonary illnesses seen. Therefore, the diagnostic approach
to the evaluation of respiratory symptoms in an HIV-infected patient
must take all these factors into consideration.
In the current era of combination antiretroviral therapy, the frequency of HIV-associated OIs and neoplasms has decreased.
In contrast, the frequency of noninfectious complications such as
chronic obstructive pulmonary disease (COPD), pulmonary arterial
hypertension (PAH), and lung cancer may be increasing. HIV infection
appears to be an independent risk factor for COPD and PAH.