Friday, April 7, 2017

Phenotyping Before Starting Treatment in COPD? (Free full text from Journal of COPD 2017)

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous and complex disease with great morbidity and mortality. Despite the new developments in the managements of COPD, it was recognized that not all patients benefit from the available medications. Therefore, efforts to identify subgroups or phenotypes had been made in order to predict who will respond to a class of drugs for COPD. 
http://www.tandfonline.com/eprint/JjF9xAcnsrjwNYAuysBI/full
This review will discuss phenotypes, endotypes, and subgroups such as the frequent exacerbator, the one with systemic inflammation, the fast decliner, ACOS, and the one with co-morbidities and their impact on therapy. It became apparent, that the “inflammatory” phenotypes: frequent exacerbator, chronic bronchitic, and those with a number of co-morbidities need inhaled corticosteroids; in contrast, the emphysematous type with dyspnea and lung hyperinflation, the fast decliner, need dual bronchodilation (deflators). However, larger, well designed studies clustering COPD patients are needed, in order to identify the important subgroups and thus, to lead to personalize management in COPD.

This is an Accepted Manuscript of an article published by Taylor & Francis in COPD: Journal of Chronic Obstructive Pulmonary Disease on 7 April 2017, available online: http://www.tandfonline.com/eprint/JjF9xAcnsrjwNYAuysBI/full

1 comment:

  1. For the past few years I have had difficulty working out in yard, then in 2015 it got harder and harder to breathe. After many tests, it was a CT scan that showed COPD, emphysema and scarring in my lungs. I quit smoking 8 years ago but the damage has been done. I got to a point I couldn't catch my breath and was coughing so hard I thought the top of my head would blow off, nothing was really working to help my condition. Finally i started on COPD herbal formula i purchased from GENERAL HERBAL HEALTH CENTER, i read alot of positive reviews from other patients who used the COPD herbal treatment on their website: http://generalhealthherbalcental.simplesite.com . I used the herbal remedy for 4 weeks, its effects on COPD is amazing, all my symptoms gradually faded away, i breath very more freely now! I recommend this COPD herbal formula for all COPD/Emphysema sufferers

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    Sarah Jones
    New Jersey
    USA

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