World TB Day 2017 (special Lancet 2017 article)

Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia. Although tuberculosis control has been effective in some regions of the world, these gains are threatened by the increasing burden of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. XDR tuberculosis has evolved in several tuberculosis-endemic countries to drug-incurable or programmatically incurable tuberculosis (totally drug-resistant tuberculosis). 

This poses several challenges similar to those encountered in the pre-chemotherapy era, including the inability to cure tuberculosis, high mortality, and the need for alternative methods to prevent disease transmission. This phenomenon mirrors the worldwide increase in antimicrobial resistance and the emergence of other MDR pathogens, such as malaria, HIV, and Gram-negative bacteria. MDR and XDR tuberculosis are associated with high morbidity and substantial mortality, are a threat to health-care workers, prohibitively expensive to treat, and are therefore a serious public health problem. In this Commission, we examine several aspects of drug-resistant tuberculosis. The traditional view that acquired resistance to antituberculous drugs is driven by poor compliance and programmatic failure is now being questioned, and several lines of evidence suggest that alternative mechanisms—including pharmacokinetic variability, induction of efflux pumps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions—are likely crucial to the pathogenesis of drug-resistant tuberculosis. These factors have implications for the design of new interventions, drug delivery and dosing mechanisms, and public health policy. We discuss epidemiology and transmission dynamics, including new insights into the fundamental biology of transmission, and we review the utility of newer diagnostic tools, including molecular tests and next-generation whole-genome sequencing, and their potential for clinical effectiveness. Relevant research priorities are highlighted, including optimal medical and surgical management, the role of newer and repurposed drugs (including bedaquiline, delamanid, and linezolid), pharmacokinetic and pharmacodynamic considerations, preventive strategies (such as prophylaxis in MDR and XDR contacts), palliative and patient-orientated care aspects, and medicolegal and ethical issues.

Full text

World Tuberculosis Day 2014: Consensus statement on the management of patients with MDR-TB and XDR-TB in Europe

Today, the European Respiratory Journal has released the publication of the TBnet consensus statement on the management of patients with MDR-TB and XDR-TB in Europe. The manuscript can be accessed online and  free of charge.

http://erj.ersjournals.com/content/early/2014/03/21/09031936.00188313

You will find important facts and information on the management of your patients as well as recommendations for therapy monitoring and documentation.

2014 World Tuberculosis Day

For the 2014 World TB (Tuberculosis) Day on 24 March 2014 many individuals, groups and organizations are standing together to spread the message of ZERO STIGMA. As the international leader in the fight against TB, Dr. Mario Raviglione, the director of the Global TB Programme at the WHO shared this ZERO STIGMA message. Take up his call to action and join the cause! 

Roadmap for Childhood Tuberculosis

"Any child who dies from TB is one child too many," said Dr Mario Raviglione, Director, Global Tuberculosis Programme at WHO in commenting on the importance of this campaign. "TB is preventable and treatable, and WHO is working towards translating this roadmap to action in countries to stop children dying."

To build public awareness and offer a plan of action, in 2013 a group of seven partner organizations worked together to produce a new "Roadmap for Childhood Tuberculosis" with leadership from the Stop TB Partnership's Childhood TB Subgroup, the global umbrella that advocates for all TB-related topics.

Ending AIDS, Tuberculosis and Malaria: How the Global Fund Can Make the Difference

We are happy to invite you to very important event at European Parliament: conference

Ending AIDS, Tuberculosis and Malaria: How the Global Fund Can Make the Difference

8 April, 14.00-16:00, European Parliament, Room ASP 5E2

 

TBNET Academy: FREE fellowships grants

The 2nd TBNET Academy will take place in Chisinau, Moldova from May 19th to May 23rd, 2013.

The TBNET-Academy provides a forum for young clinicians and scientists in the field of TB to exchange ideas and to learn from each other under expert guidance and mentorship. Especially the 2nd TBNET-Academy in Chisinau will draw attention to the particular problems of TB control and treatment in high incidence countries by addressing local problems and learning from international and local experts.

More information:

Keynote lectures on:
Tuberculosis in Europe
TBNET: Collaborative Research in Europe
The future on TB treatment
Non tuberculous mycobacteria infections
Tb control and elimination
Special features:
How to prepare a research project?
How to get funded?
How to write a manuscript?

Opening of the photo exhibition „STOP TB! Tuberculosis - A worldwide menace“ 9th of November 2012

Today we are happy to present you special report from our friend Cordula from Take That TB organization about the opening of photo exhibition dedicated to Tuberculosis! We are highlighting today tuberculosis as one of the dangerous communicable disease, which can be prevented and treated with success!

Tuberculosis is a forgotten illness in Europe. In many other parts of the world this illness is still rife  and shows in connection with AIDS a menace for the world health.  
On the 9th of November 2012 the photo exhibition „STOP TB! Tuberculosis - A worldwide menace“  was opened. It was carried out in cooperation with the stop TB Partnership. 

The exhibition shows impressing photo reports from  photojournalists like Pulitzer prizewinner David Rochkind. They all have documented the situation of tuberculosis patients worldwide for several years. After an introductory talk of the epidemiologist Dr. Stefanie Castell of the Helmholtz centre Braunschweig that inspired the audience by its descriptiveness, possibilities of the fight against TB were discussed with a high-carat occupied panel discussion. During this panel discussion Dr. Peter Reff of the KfW developing bank said, ’It is a scandal that all 20 seconds a person must die because of a remediable illness like tuberculosis. Prof. Dr. Klaus Fleischer of the German leprosy and tuberculosis relief (DAHW) underlined that tuberculosis is above all a poverty illness. Mrs. Diekwisch of the pharmaceutical campaign BUKO and Mrs. Heykes-Uden of the tuberculosis advice centre of the region Hannover agreed that poverty fight, the improvement of the living conditions and access to education are most important components in the fight against tuberculosis.

The appearance of Cordula whose tuberculosis illness was not recognised in Germany more than 15 months by several doctors was very moving. The courageous young woman reported that many doctors did not recognise her illness for a long time and she also talked about unawareness about tuberculosis. Now the young woman fights together with the German leprosy and tuberculosis relief (DAHW) and with her own patient organization for a better understanding and knowledge of the illness in Germany. „ Such cases show us that we must fight for more awareness of tuberculosis in Germany, and our exhibition contributes an important part to it“, both curators Harro Schmidt and 
Dr. Matthias Stehr added.

The exhibition runs from November 10th to December 16th 2012 in the arts centre “Faust” in Hannover. 

Opening hours:
Thursdays + Friday 4pm - 8pm
Saturday + Sunday 2pm - 6pm

Photo exhibition at Hannover: STOP TB! Tuberculosis - A Global Threat

"STOP TB! Tuberculosis - A Global Threat. "Under this title, Kunsthalle Faust, Hannover cooperates with the Stop TB Partnership for the first time. A large selection of photos of the "Images to Stop Tuberculosis Photo Award 'in Europe following the successfully conducted, great photojournalism project (the Stop TB Partnership in Rio de Janeiro) will be shown by the work of five internationally renowned photographer Jean Chung, Sailendra Kharel, Riccardo Venturi, David Roch Child and David Orr. The photojournalists have documented the situation of TB patients worldwide.

Picture by Jean Chung

Showing more than 50 photographic works and four photo stories as a multimedia presentation, the large-size exhibits impressively show the suffering and the hope of the people who are affected by tuberculosis. In the exhibition, unique shots from different countries are shown, which are most affected by the disease, such as India, Nepal, Sudan and Brazil. The representation of a Sudanese boy who is cared for by his parents lovingly or moribund patients in an Indian hospital left a profound and lasting impressions. Other photographs show patients treated successfully and provide unique examples of the perseverance of the individual and the hope for a cure, despite serious illness.

Picture by Jean Chung